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High‐Temperature Short‐Time Heat Inactivation of HIV and Other Viruses in Human Blood Plasma

 

作者: Stanley E. Charm,   Steven Landau,   Bolanle Williams,   Bernard Horowitz,   Alfred M. Prince,   Donna Pascual,  

 

期刊: Vox Sanguinis  （WILEY Available online 1992）
卷期: Volume 62, issue 1  

页码: 12-20

 

ISSN:0042-9007

 

年代: 1992

 

DOI:10.1111/j.1423-0410.1992.tb01160.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

AbstractAn ultra‐short‐time heating system was used to process blood plasma spiked with various viruses (HIV, vesicular stomatitis virus, encephalomyocarditis virus). Virus reduction and recovery of plasma proteins were measured at various temperatures from 65 to 85 °C. Processing at 77 °C and 0.006 s resulted in a high level of virus kill, including ≥ 4.4 log10HIV, while maintaining protein structure and activity essentially

 

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