In the United States, an estimated 36,000 new cases of endometrial cancer were to be diagnosed in 1986 with 2900 deaths attributed to this disease (6). Cancer of the uterus itself accounts for approximately 13% of all cancers in women. The diagnosis of uterine cancer brings with it feelings of fear, mutilation, insults to self-esteem and sexuality, as well as feelings of depersonalization and loss of body image. The complexity of this illness dictates a special need for nurses, as members of the health care team, to provide compassionate, holistic and quality nursing care to these clients. This study of 30 participants (15 paired registered nurses and their clients) researches the relationship between the registered nurses' perception and the clients' perception of human need fulfillment alterations in the client with uterine cancer. Nursing's human need theory was the theoretical framework used in this study because of its appropriateness to the subject matter of human needs and in the alteration in fulfillment of human needs for the client with uterine cancer. The findings of this study revealed that the registered nurse sample perceived human need fulfillment alterations similarly to the client with uterine cancer. While there were no significant statistical differences in the two groups' individual rankings of human needs, two important trends were noted. Nurses as a group tended to rank physiological needs as of greatest importance for these 15 clients. In contrast, the 15 clients as a group rated emotional, spiritual, and psychosocial needs higher.