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Second Interim Report of the Nation-Wide Collaborative Study on the Long-Term Effects of Bromocriptine in the Treatment of Parkinsonian Patients

 

作者: Takao Nakanishi,   Makoto Iwata,   Ikuo Goto,   Ichiro Kanazawa,   Hisayuki Kowa,   Tohru Mannen,   Yoshikuni Mizuno,   Hiroshi Nishitani,   Norio Ogawa,   Akira Takahashi,   Kunio Tashiro,   Hideo Tohgi,   Nobuo Yanagisawa,  

 

期刊: European Neurology  (Karger Available online 1989)
卷期: Volume 29, issue 1  

页码: 3-8

 

ISSN:0014-3022

 

年代: 1989

 

DOI:10.1159/000116446

 

出版商: S. Karger AG

 

关键词: Parkinson’s disease;Levodopa;Bromocriptine;Treatment;Side effects

 

数据来源: Karger

 

摘要:

The interim data obtained up to the end of the 2nd year of the nation-wide multicentric cooperative study on the long-term effects of bromocriptine in parkinsonian patients revealed the following results. Firstly, the bromocriptine monotherapy could be continued in about 40% of the patients at the mean maintenance dose of 10.8 mg daily. Secondly, the additional use of bromocriptine in parkinsonian patients already treated with levodopa had a favorable influence on late side effects of levodopa such as on-off phenomenon and dyskinesia. No significant difference has been found so far as to the management of the wearing-off phenomenon between the patients with levodopa alone and those with levodopa and bromocriptine.

 

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