Natural antagonists of platelet‐activating factor
作者:
David Hosford,
Jean‐Michel Mencia‐Huerta,
Clive Page,
Pierre Braquet,
期刊:
Phytotherapy Research
(WILEY Available online 1988)
卷期:
Volume 2,
issue 1
页码: 1-24
ISSN:0951-418X
年代: 1988
DOI:10.1002/ptr.2650020102
出版商: John Wiley&Sons, Ltd.
关键词: Platelet‐activating factor, (PAF);natural antagonists;ginkgolides;lignans;gliotoxins
数据来源: WILEY
摘要:
AbstractSeveral groups of antagonists of platelet‐activating factor (PAF) are reviewed. The characteristics of PAF binding sites on mammalian cell membranes are described together with the activities of non‐specific and synthetic PAF‐antagonists. The specificity of the ginkgolides to bind to PAF‐receptors is discussed and the effects of these natural products in a range of biological systems is emphasized. Other groups of natural PAF‐antagonists described are the lignans and gliotoxin related compounds. The structural chemistry, structure‐activity relationships and pharmacological properties of these drugs are compared to the
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