Radioactively labelled epoxides part II. (1) tritium labelled cyclohexene oxide, transstilbene oxide and phenanthrene 9,10‐oxide
作者:
Franz Oesch,
Alan J. Sparrow,
Karl L. Platt,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1980)
卷期:
Volume 17,
issue 1
页码: 93-102
ISSN:0362-4803
年代: 1980
DOI:10.1002/jlcr.2580170110
出版商: John Wiley&Sons, Ltd.
关键词: Alkene oxides;Arene oxides;Complex metal hydrides;Tritium
数据来源: WILEY
摘要:
AbstractTritium labelled cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide were prepared with specific activities of 0.7 ‐ 1.1 mCi per mmole starting with monoor diketo compounds.Tritium was introduced by reducing the ketone precursors with tritiated complex metal hydrides.The resulting alcohols were transformed to the epoxides by methods described for the unlabelled compounds.The syntheses require only two or three steps and yield cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide, important substrates for the study of epoxide hydratase and glutathione S‐transferases in high radiochem
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