Granulomatous Interstitial Nephritis after a Jejunoileal Bypass: An Ultrastructural and Histochemical Study
作者:
Regina Verani,
Marwan Nasir,
Richard Foley,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 1
页码: 51-55
ISSN:0250-8095
年代: 1989
DOI:10.1159/000167935
出版商: S. Karger AG
关键词: Intestinal bypass;Renal granulomas;Interstitial nephritis;Lectin stain
数据来源: Karger
摘要:
We present a case of granulomatous interstitial nephritis and renal failure after a jejunoileal bypass for obesity. Improvement of the renal function occurred after reversal of the intestinal bypass. The renal biopsy showed an interstitial nephritis, oxalate crystal deposition and several aggregates of multinucleated giant cells related to the crystal material (granulomatous reaction). By ultrastructural and histochemical studies we demonstrated mitochondrial alterations in the tubular epithelial cells, and we suggested the proximal tubule origin of the giant cells. The association of the oxalate crystals with damaged tubules and giant cells suggests that the oxalate crystals are responsible for these alterations. The possibility of an associated immunological process as the cause of the interstitial nephritis cannot be excluded.
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