Polymorphous low-grade adenocarcinoma (PLGA) is a recently described, relatively uncommon tumor that arises preferentially in minor salivary glands, favoring the palace. The tumor is characterized by a proliferation of uniform, cytologically bland cells and exhibits a broad range of growth patterns including tubular, solid, cribriform, and fascicular. A focal papillary growth pattern may also be observed. Tumors are infiltrative at their borders with a single-file pattern of invasion being most common. Intraneural and perineural invasion is also a frequent finding. The histologic differential diagnosis includes both benign and malignant tumors. Clinically, PLGA follows an indolent course. These tumors are best treated by complete but conservative excision, and there is no compelling evidence that postoperative radiation or chemotherapy is of benefit. Likewise, radical neck dissection is not of benefit unless metastatic cervical disease is present. Although recurrent or regional disease may develop, distant metastatic disease is distinctly uncommon.