Bithermic Complement Activation in Cryoglobulinaemic Serum
作者:
Ursula Rother,
Klaus Rother,
Hans D. Flad,
Peter A. Miescher,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1972)
卷期:
Volume 2,
issue 2
页码: 59-65
ISSN:0014-2972
年代: 1972
DOI:10.1111/j.1365-2362.1972.tb00570.x
出版商: Blackwell Publishing Ltd
关键词: Cryoglobulin;cryoprecipitate;complement activation temperature in vitro
数据来源: WILEY
摘要:
Abstract.Cryoglobulin precipitates of the mixed type, containing 19 S IgM and 7 S IgG gamma globulin, were isolated from a patient serum and the interaction with serum C was studied. Loss of C activity in human serum incubated with cryoprecipitate was accompanied by the generation of C3 activity in the cryoglobulin aggregates. Complete dissociation of cryoprecipitation and the interaction of the precipitates with C was achieved at temperatures below 22°C and above 32°C respectively. The normal C titre in fresh serum of a cryoglobulinaemic patient was significantly reducedin vitroby first cooling and then rewarming the serum. The possible pathogenic role of the bithermic C activation in cryoglobulinaemic vascular lesions is discusse
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