SummaryEpileptic grand mal seizures as well as electroconvulsive therapy (ECT) induce a transient robust prolactin hypersecretion. Similar prolactin response has been demonstrated following pentylenetetrazol (Cardiazol)-induced seizures in two schizophrenic female patients. A slight increase in cortisol secretion but no change in thyroid stimulating hormone and growth hormone levels suggest that the prolactin response is a specific hormonal change during convulsive treatments.