High-Dose (480 mg/day) Tamoxifen with Etoposide: A Study of a Potential Multi-Drug Resistance Modulator
作者:
Michael J. Millward,
Ernst A. Lien,
Angela Robinson,
Brian M.J. Cantwell,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 1
页码: 79-83
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227315
出版商: S. Karger AG
关键词: Tamoxifen;Drug resistance
数据来源: Karger
摘要:
Tamoxifen and its principle metabolite N-desmethyltamoxifen can modulate multi-drug resistance in vitro. Tamoxifen 480 mg/day was given for 6 days with oral etoposide on days 4-6 to 17 patients with advanced solid tumours. Venous thrombosis (2 patients), reversible neurological toxicity (1 patient), and WHO grade III nausea/vomiting (3 patients) related to tamoxifen were observed but overall toxicity was manageable. One partial response occurred in 15 assessable patients. Mean plasma concentrations of tamoxifen and N-desmethyltamoxifen increased to 4.3 μmol/l and 2.7 μmol/l, respectively, by day 6. Plasma concentrations corresponding to active in vitro levels were attained by most patient
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