Modulation of Amnionic Adenylate Cyclase and cAMP Phosphodiesterase by Prostaglandins E1and F2α
作者:
F. Vesce,
C. Tarabbia,
A. Farina,
S. Travagli,
M.C. Pareschi,
A. Portolan,
C. Biondi,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 37,
issue 2
页码: 77-82
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292529
出版商: S. Karger AG
关键词: Adenylate cyclase;cAMP-PDE;Amnion;Labor;PGE1;PGF2α
数据来源: Karger
摘要:
The action of prostaglandins E1 and F2α on adenylate cyclase and cAMP phosphodiesterase was assayed in cell membrane fractions of amnion obtained before and after labor from term physiological pregnancies. Both prostaglandins stimulate the activity of adenylate cyclase in a dose-dependent manner. After spontaneous delivery both prostaglandins stimulate the activity of phosphodiesterase at lower doses and inhibit it at higher ones while the stimulatory effect of low doses is missing before labor. Such a behavior could represent a mechanism for the preservation of the cAMP-mediated processes throughout the entire event of delivery.
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