This paper describes the results of an experimental study of the microwave coagulation of VX‐2 renal tumors implanted in rabbits. The rabbits undergoing microwave treatment exhibited a satisfactory survival rate and a complete response to treatment, as verified by histological examination. All the rabbits receiving no treatment died within 6 weeks of implantation of the VX‐2 carcinoma. These results indicate that microwave coagulation may be a curative method of treatment for a relatively small renal tumor. Intraoperative real‐time ultrasonic scanning permits the percutaneous microwave coagulation of renal cancer in a clinical situ