Pharmacological properties of a lyophilizate fromGaleopsis ladanumon the central nervous system of rodents
作者:
R. Czarnecki,
T. Librowski,
K. Zélbala,
S. Kohlmünzer,
期刊:
Phytotherapy Research
(WILEY Available online 1993)
卷期:
Volume 7,
issue 1
页码: 9-12
ISSN:0951-418X
年代: 1993
DOI:10.1002/ptr.2650070104
出版商: John Wiley&Sons, Ltd.
关键词: Galeopsis ladanumL. extract;acute toxicity;spontaneous locomotor activity;hexobarbital
数据来源: WILEY
摘要:
AbstractThe influence of a fraction obtained fromGaleopsis ladanumL. on the central nervous system of rodents was examined. The results of these investigations show that the fraction impeded CNS activity. It is practically nontoxic and at a dose of 2000 mg/kg i.p. it does not have a soporific influence on mice. It reduces considerably the spontaneous locomotor activity of mice as well as the locomotor activity of mice stimulated by caffeine, but did not influence the locomotor activity induced by amphetamine. The extract did not exhibit a synergetic effect with barbiturates. The results suggest that the pharmacological activity of the extract resembled the activity of drugs which generally depress the CNS, being on the border between ataractic and sedative drugs.
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