T Helper Cell Control of B Cell Development and Isotype Expression
作者:
ThèzeJacques,
LeclercqLise,
LiseMarie,
期刊:
International Reviews of Immunology
(Taylor Available online 1986)
卷期:
Volume 1,
issue 2
页码: 183-212
ISSN:0883-0185
年代: 1986
DOI:10.3109/08830188609056606
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The supernatant of the T helper cell clone 52.3 (52.3-SN) was shown to induce polyclonal activation of resting B cells. 52.3-SN acts on most small B cells and through the allogeneic barrier. This supernatant induces cell size increase, RNA and DNA synthesis, and appearance of interleukin-2 and transferrin receptor. These results are interpreted as indicating the existence of a B Cell Activating Factor (BCAF) acting on resting B cells in an MHC-unrestricted way.TH cells can be obtained in an intermediate state of activation where they secrete lymphokines leading to B cell proliferation and not the biological activities leading to plasmocyte development. TH cell clones can induce sIgG−and sIgA−unprimed B cells to switch and express all classes and subclasses of immunoglobulin. The bulk of the response consists of IgM. Among the non IgM isotypes, IgG1and IgA predominate. The supernatants prepared from TH cells reproduce these effects.
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