Non-Parallel Secretion of Pancreatic Enzymes
作者:
B. de Waele,
A. Lambin,
A. de Smul,
R. Kiekens,
期刊:
Digestion
(Karger Available online 1979)
卷期:
Volume 19,
issue 1
页码: 15-22
ISSN:0012-2823
年代: 1979
DOI:10.1159/000198317
出版商: S. Karger AG
关键词: Amino acids;Amylase;Bile;Carboxypeptidase;Chymotrypsinogen;Enzyme;Lipase;Pancreatic juice;Rat;Trypsinogen
数据来源: Karger
摘要:
Chronic drainage of pancreatic juice in rats results in a non-parallel secretion of digestive enzymes. The concentration of trypsinogen, chymotrypsinogen, procarboxypeptidase B and lipase increases continuously whereas that of amylase drops. An amino acid mixture given intravenously does not affect this dissociation. Reinfusion of bilio-pancreatic juice into the duodenum on the contrary influences the relative enzyme release: the increase in concentration of the three proteolytic enzymes and of lipase is less pronounced over the 72-hour study period; amylase concentration remains unaffected. In the absence of an intravenous amino acid feeding the pancreatic protein output is more than halved and a negative nitrogen balance is observed. Reinfusion of bilio-pancreatic juice does not alter the total protein output. This report confirms the persistence of a dissociation in the rate of enzyme release in rats with chronic pancreatic fistula despite sufficient protein administration and intestinal reintroduction of bilio-pancreatic juice.
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