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Non-Parallel Secretion of Pancreatic Enzymes

 

作者: B. de Waele,   A. Lambin,   A. de Smul,   R. Kiekens,  

 

期刊: Digestion  (Karger Available online 1979)
卷期: Volume 19, issue 1  

页码: 15-22

 

ISSN:0012-2823

 

年代: 1979

 

DOI:10.1159/000198317

 

出版商: S. Karger AG

 

关键词: Amino acids;Amylase;Bile;Carboxypeptidase;Chymotrypsinogen;Enzyme;Lipase;Pancreatic juice;Rat;Trypsinogen

 

数据来源: Karger

 

摘要:

Chronic drainage of pancreatic juice in rats results in a non-parallel secretion of digestive enzymes. The concentration of trypsinogen, chymotrypsinogen, procarboxypeptidase B and lipase increases continuously whereas that of amylase drops. An amino acid mixture given intravenously does not affect this dissociation. Reinfusion of bilio-pancreatic juice into the duodenum on the contrary influences the relative enzyme release: the increase in concentration of the three proteolytic enzymes and of lipase is less pronounced over the 72-hour study period; amylase concentration remains unaffected. In the absence of an intravenous amino acid feeding the pancreatic protein output is more than halved and a negative nitrogen balance is observed. Reinfusion of bilio-pancreatic juice does not alter the total protein output. This report confirms the persistence of a dissociation in the rate of enzyme release in rats with chronic pancreatic fistula despite sufficient protein administration and intestinal reintroduction of bilio-pancreatic juice.

 

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