Variability in Sib Pair Genetic Identity
作者:
B.K. Suarez,
T. Reich,
P.M. Fishman,
期刊:
Human Heredity
(Karger Available online 1979)
卷期:
Volume 29,
issue 1
页码: 37-41
ISSN:0001-5652
年代: 1979
DOI:10.1159/000153013
出版商: S. Karger AG
关键词: Sibs;Identity by descent (IBD);Chromosomes;Crossing over
数据来源: Karger
摘要:
Using a realistic model of meiotic crossing over the variability in full sib genetic identity is estimated by simulating 200 independent pairs of sibs. The standard deviation of the percentage of the autosomal genome identical by descent (IBD) was found to be about 0.056. Simulations of sibships larger than size two revealed that the average within sibship standard deviation is between 0.054 and 0.056, thus indicating that sib pair variability is insensitive to the nonindependence structure present when considering all possible sib pairs contained in a large sibship.
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