Role of Plasminogen Activator Inhibitor Type 1 in the Pathogenesis of Coronary Artery Diseases
作者:
Justo Aznar,
Amparo Estellés,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1994)
卷期:
Volume 24,
issue 4
页码: 243-251
ISSN:1424-8832
年代: 1994
DOI:10.1159/000217108
出版商: S. Karger AG
关键词: Plasminogen activator inhibitor type 1;Coronary disease;Angina;Heart disease;Fibrinolysis
数据来源: Karger
摘要:
Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an independent thrombotic risk factor. In addition, PAI-1 synthesis is greater in the atherosclerotic vessels than in the normal vessels and this can also constitute an atherogenic risk factor. There is a good correlation between insulinaemia and PAI-1, but it has not been demonstrated that the circulating level of PAI-1 depends exclusively on insulinaemia. The increased levels of PAI-1 correlate with other coronary risk factors, especially hypertriglyceridaemia, but high PAI-1 levels are also found in normolipaemic patients. Vascular synthesis of PAI-1 can be promoted by high levels of circulating lipoprotein a. Finally, an exercise programme can increase the fibrinolytic activity of heart disease patients towards normal.
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