This cross-sectional study describes physical health, psychological well-being, role satisfaction, and social support as reported by employed women who experience perimenstrual symptoms in comparison with employed women who do not experience perimenstrual symptoms. Both groups were similar in their employment and educational status. Yet, in addition to more physical health problems and a lower sense of psychological well-being, the symptomatic women were less satisfied with various aspects of their social lives and reported less social support. Results of this study provide empirical data from which to begin developing interventions directed toward the symptomatic woman's lifestyle and not just the specific perimenstrual symptom she experiences.