SummaryWe have discussed our experiences with 11 patients who had colorectal disorders and hematologic diseases. Most (9 of 11) had anorectal problems which fell into the categories of local infection, sepsis, and bleeding. Six of the nine patients with anorectal disorders had had anorectal disease previously, before recognition of their hematologic disease. Methods of treatment and general care of patients with concurrent proctologic and hematologic disorders are discussed. Chemotherapy, platelet transfusions, and other supportive measures are used in the effective treatment of the anorectal disorders.