AbstractDeuterium chemistry is still quite costly, mainly because of the high prices of deuterated compounds needed for syntheses. Furthermore, the risk of diluting isotopically the compounds prepared is considerable. These disadvantages can be alleviated, if i) the deuterium of the D‐donator is exchanged efficiently, ii) highly deuterated solvents and reactants can is be prepared conveniently on a laboratory scale, and iii) compounds, which have been isotopically diluted can be reconcentrated conveniently. Fulfillments of these requirements allows for research in deuterium chemistry on a close to pilot plant scale at tolerable costs.With this aim in mind, basic principles of batch deuterations on pilot plant scale with low grade heavy water discussed. By up‐grading D2O wastes, close to 98 % of the deuterium employed for reaction can be incorporated into the substr