ABSTRACTA histochemical study of the presence of catecholamine‐containing cells (chromaffin cells) in human skin which had been treated by chromate‐bichromate solution according to Hillarp and Hökfelt then counter‐stained with various methods, was carried out.Small numbers of brown granules were disclosed in the upper part of the chromated normal dermis. They stained green with Giemsa or toluidine blue, showing similar staining properties to the adrenal medulla of rabbits treated in the same way. They were also found in large numbers in nevus pigmentosus and blue nevi, but were rarely seen in Recklinghausen's disease and atopic dermatitis.Although the above‐mentioned brown pigment is not likely to be catecholamine, other possibilities of the nature of the granules are discussed, with special reference to melanin and lipid