Dichloromethylene Biphosphonate Retards Femoral Expansion in Normal and Castrated Adult Male Rats
作者:
Carole S. Wink,
Elizabeth M. Hill,
期刊:
Cells Tissues Organs
(Karger Available online 1988)
卷期:
Volume 132,
issue 4
页码: 321-323
ISSN:1422-6405
年代: 1988
DOI:10.1159/000146595
出版商: S. Karger AG
关键词: Rat;Femur;Expansion;Cl2MBP;Castration
数据来源: Karger
摘要:
This study reports the effects of dichloromethylene biphosphonate (Cl2MBP), an inhibitor of bone remodeling, on femoral expansion in four groups of adult male rats; (1) sham-operated controls; (2) sham operated + injections of Cl2MBP; (3) castrated (osteoporotic), and (4) castrated + injections of Cl2MBP. After controlling for body weight, analyses of covariance revealed significant differences in total femoral width between animals that had received Cl2MBP and those that had not. The results indicated that Cl2MBP treatment retarded femoral expansion in both castrated and normal adult male rats.
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