Endocrine Features in Eutestosteronemic Women with Polycystic Ovaries
作者:
Keisuke Wada,
Atsushi Imai,
Toshiya Itoh,
Miki Nishigaki-Nakagawa,
Ryo Misao,
Teruhiko Tamaya,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 37,
issue 2
页码: 106-109
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292535
出版商: S. Karger AG
关键词: Sex hormone binding globulin;Testosterone;Gonadotropin;Polycystic ovaries;Ultrasonography
数据来源: Karger
摘要:
We attempted to assess the association between hyperandrogenemia and inappropriate gonadotropin secretion in women with polycystic ovaries (PCO). Thirty-one patients diagnosed as PCO by ultrasonography were divided into two subgroups: 17 with high serum total testosterone (T) level ( > 0.5 ng/ml) and 14 with normal serum total T level ( < 0.5 ng/ml). Both subgroups presented for the complaints of oligomenorrhea and/or hirsutism. The control group consisted of 15 women with regular ovulation for reference data collection. The PCO subjects with normal T, but not those with high T, revealed remarkable depletion of sex hormone binding globulin (SHBG), as compared with control. The PCO subject groups with high and normal serum T did not differ with respect to estrogen level, androgen level, follicle-stimulating hormone and prolactin levels, and SHBG concentration. Solely serum luteinizing hor-mon (LH) level was observed to be higher in those with high T, as typical features, than another subgroup or control. These data suggest that an increase in bioactive T as a result of decrease in serum SHBG or LH elevation may contribute to ovarian dysfunction in the patient with PCO.
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