Translocation (11;14): A cytogenetic anomaly associated with B‐cell lymphomas of non‐follicle centre cell lineage
作者:
Elisabeth Vandenberghe,
Chris De Wolf‐Peeters,
Joost Van Den Oord,
Ivonna Wlodarska,
Jan Delabie,
Michel Stul,
José Thomas,
Jean‐Louis Michaux,
Cristina Mecucci,
Jean‐Jacques Cassiman,
Herman Van Den Berghe,
期刊:
The Journal of Pathology
(WILEY Available online 1991)
卷期:
Volume 163,
issue 1
页码: 13-18
ISSN:0022-3417
年代: 1991
DOI:10.1002/path.1711630104
出版商: John Wiley&Sons, Ltd.
关键词: Translocation (11:14);diffuse small cleaved cell lymphoma;bcl 1
数据来源: WILEY
摘要:
AbstractNine patients with t(11;14) and B non‐Hodgkin's lymphomas composed of small to intermediately sized cells with irregular nuclei are described. Immunophenotyping was performed on seven cases, which were M+, D− with light chain restriction, CD5+, CD10−, and CD20+, suggesting that they were non‐follicle centre cell lymphomas. The translocation (11;14) (in three cases the only cytogenetic anomaly) was associated with rearrangement of bcl‐1 in four of the five cases investigated. Translocation (11;14) has been described in an apparently heterogeneous group of low‐grade lymphoid malignancies which we suggest have a non‐follicle centre cell lineage in common. This translocation may be associated with these lymphomas in the same way that t(14; 18) is associated with follicle centre c
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