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Translocation (11;14): A cytogenetic anomaly associated with B‐cell lymphomas of non‐follicle centre cell lineage

 

作者: Elisabeth Vandenberghe,   Chris De Wolf‐Peeters,   Joost Van Den Oord,   Ivonna Wlodarska,   Jan Delabie,   Michel Stul,   José Thomas,   Jean‐Louis Michaux,   Cristina Mecucci,   Jean‐Jacques Cassiman,   Herman Van Den Berghe,  

 

期刊: The Journal of Pathology  (WILEY Available online 1991)
卷期: Volume 163, issue 1  

页码: 13-18

 

ISSN:0022-3417

 

年代: 1991

 

DOI:10.1002/path.1711630104

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Translocation (11:14);diffuse small cleaved cell lymphoma;bcl 1

 

数据来源: WILEY

 

摘要:

AbstractNine patients with t(11;14) and B non‐Hodgkin's lymphomas composed of small to intermediately sized cells with irregular nuclei are described. Immunophenotyping was performed on seven cases, which were M+, D− with light chain restriction, CD5+, CD10−, and CD20+, suggesting that they were non‐follicle centre cell lymphomas. The translocation (11;14) (in three cases the only cytogenetic anomaly) was associated with rearrangement of bcl‐1 in four of the five cases investigated. Translocation (11;14) has been described in an apparently heterogeneous group of low‐grade lymphoid malignancies which we suggest have a non‐follicle centre cell lineage in common. This translocation may be associated with these lymphomas in the same way that t(14; 18) is associated with follicle centre c

 

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