Myocardial K kinetics in rats on Mg-deficient diet.
作者:
MaddenJ A,
SmithG A,
LlauradoJ G,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1982)
卷期:
Volume 1,
issue 4
页码: 323-329
ISSN:0731-5724
年代: 1982
DOI:10.1080/07315724.1982.10719002
出版商: Routledge
数据来源: Taylor
摘要:
Kinetics and distribution of K were studied in myocardiuum of chronic Mg-deficient rats. The experimental design was as follows. Rats were fed either Mg-deficient or control diet for 30 days. They were then injected with 0.2 mCi of K-43. One half hour after injection they were killed and a segment of myocardium was washed with nonradioactive Krebs solution in a special chamber. Radioactivity remaining in the tissue was recorded continuously for 1 hour. A three-compartment model (extracellular, main intracellular, and subcellular) was used; transport rate constants (kij) and relative compartment sizes (qj) were determined. In myocardium of Mg-deficient rats the kij's and q's indicated greatly reduced intracellular accumulation of K but a large accumulation of K within the subcellular compartment probably mitochondrial. There was also some enlargement of the extracellular compartment. The extracellular to overall intracellular ratio for K increased 46% in Mg-deficient myocardium. The hypothesis that dietary Mg deficiency affects Na-K pump function is discussed.
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