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Characteristic patterns of verbal memory function in patients with Huntington's disease

 

作者: ASTRI J. LUNDERVOLD,   IVAR REINVANG,   ARVID LUNDERVOLD,  

 

期刊: Scandinavian Journal of Psychology  (WILEY Available online 1994)
卷期: Volume 35, issue 1  

页码: 38-47

 

ISSN:0036-5564

 

年代: 1994

 

DOI:10.1111/j.1467-9450.1994.tb00931.x

 

出版商: Blackwell Publishing Ltd

 

关键词: Huntington's disease;dementia;verbal memory function

 

数据来源: WILEY

 

摘要:

Various aspects of verbal memory in patients with Huntington's disease (HD) were studied using the California Verbal Learning Test (CVLT). We tested if the level and interplay between 5 parameters of different memory mechanisms and processes were sufficiently specific to allow acceptable discrimination between patients with HD, patients with Parkinson's disease (PD), and patients without known CNS disease or injury. The HD‐patients were characterized by a deficit in acquisition, elevated rates of recall errors and increased use of a passive learning strategy. Preserved aspects were shown in retention over time, interference effects and recognition relative to recall. Employing multivariate classification and validation techniques, the 5 CVLT‐features demonstrated good separability between the HD‐patients and the control patients. Qualitative similarities between subgroups were suggested, but more disease‐specific data seemed necessary in further studies. A number of findings suggested a defect in the active organization of items to be encoded and recalled in HD. Similar findings in the PD‐group might indicate that this trait is common in several types of ‘subcortica

 

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