Galvanic skin response (GSR) was assessed during 10 electroconvulsive therapy (ECT) sessions with five patients to evaluate its clinical utility in monitoring ECT-induced seizures. While GSR change was consistently observed in all instances, its duration persisted far longer than did seizure activity as measured by observed tonic-clonic movements. Accordingly, and in contrast to a prior report, GSR cannot be recommended as an accurate and reliable method of monitoring ECT.