Thyroid Function and Reversal by Antidepressant Drugs of Depressive-Like Behavior (Escape Deficits) in Rats
作者:
P. Martin,
J. Massol,
J.P. Belon,
G. Gaudel,
P. Soubrié,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 18,
issue 1
页码: 21-26
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118388
出版商: S. Karger AG
关键词: Antidepressant drugs;Thyroid;Propylthiouracil;Triiodothyronine;Learned helplessness;Escape deficits
数据来源: Karger
摘要:
Several investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present study shows that the reversal by clomipramine, desipramine, imipramine and nialamide of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was markedly attenuated in hypothyroid rats (propylthiouracil, 0.05% in the drinking water). Conversely, the effect of these same antidepressants was significantly hastened in euthyroid rats given daily triiodothyronine. This supports the notion of intricate thyroid/CNS interactions in the mechanisms of action of antidepressant drugs.
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