Circulating Immune Complexes in Systemic Scleroderma and Generalized Morphea
作者:
Sean O’Loughlin,
Gerhard Tappeiner,
Robert E. Jordon,
期刊:
Dermatology
(Karger Available online 1980)
卷期:
Volume 160,
issue 1
页码: 25-30
ISSN:1018-8665
年代: 1980
DOI:10.1159/000250463
出版商: S. Karger AG
关键词: Immune complexes;Systemic scleroderma;Generalized morphea
数据来源: Karger
摘要:
There is growing evidence that pathologic changes in the vascular system are implicated in the pathogenesis of systemic scleroderma. It has been suggested that immune complex deposition may be responsible for such changes. We measured circulating immune complexes in 10 patients with severe systemic scleroderma, 1 of whom had clinical evidence of renal disease, and in 3 patients with generalized morphea. None of the patients had significantly elevated levels. Our findings suggest that although circulating immune complexes are of diagnostic and prognostic value in other collagen vascular diseases, they do not play a major role in the pathogenesis of systemic scleroderma in patients who lack clinical evidence of renal disease.
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