Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse paterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6(drug dependency, 4): atopy. 5 (asthma. 3): malignancies. 5; immune complex vasculitis, 4; thyroid disease, 2: Wells' eosinophilic cellulitis, 2; glomerulonephritis and sarcoidosis, 1 each. The skin lesions varied from urticarial papules and plaqes to purpura, pustules, and ulcerative lesions hut always included a nodular subcutaneous component, frequently as a presenting complaint. Eosinophilic panniculitis is a non‐specific finding that can signify localized disease, such as an insect bite or injection lipophagic granuloma in a drug‐dependent patient, or systemic lymphoma or immune reactive disease. Eosinophilic panniculitis in erythema nodosum is perhaps its most confusing presentat