Type IV Collagen in the Basal Membrane of Human Papillomavirus Associated Premalignant and Malignant Squamous Cell Lesions of the Uterine Cervix
作者:
T. Sorvari,
A. Sarnesto,
K. Syrjänen,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1988)
卷期:
Volume 26,
issue 4
页码: 324-331
ISSN:0378-7346
年代: 1988
DOI:10.1159/000293714
出版商: S. Karger AG
关键词: Basement membrane;Type IV collagen;Human papillomavirus;Cervical intraepithelial neoplasia;Cervical carcinogenesis;Immunohistochemistry
数据来源: Karger
摘要:
In the present study, the expression of type IV collagen associated with the basal membrane (BM) was studied histochemically (indirect immunoperoxidase-antiperoxidase) in cervical human papillomavirus (HPV) lesions (diagnosed using in situ DNA hybridization) of different grades. The expression of type IV collagen in premalignant epithelial lesions (HPV with and without cervical intraepithelial neoplasia) was identical with that in the BM of normal exocervical epithelium, in contrast to 60% (3/5) of carcinoma in situ lesions and 90% (10/11) of invasive carcinomas, where the staining pattern was interrupted and the staining intensity reduced. Thus, the expression of type IV collagen seems to remain unchanged during the entire spectrum of premalignant stages of cervical HPV lesions. This suggests that the squamous epithelial cells responsible for the formation of the BM are not affected by this virus at early stages of the disease, and immunohistochemical recognition of an intact staining pattern of type IV collagen may signify well-preserved basal cell function (confined to nonmalignant?) HPV-infected squamous epithelium.
点击下载:
PDF
(2785KB)
返 回