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Human leukocyte interferon‐mediated granulopoietic differentiation arrest and its abrogation by lithium carbonate

 

作者: Dharmvir S. Verma,   Gary Spitzer,   Jordan U. Gutterman,   Miloslav Beran,   Axel R. Zander,   Kenneth B. McCredie,  

 

期刊: American Journal of Hematology  （WILEY Available online 1982）
卷期: Volume 12, issue 1  

页码: 39-46

 

ISSN:0361-8609

 

年代: 1982

 

DOI:10.1002/ajh.2830120106

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: human leukocyte interferon (HLIF);lithium carbonate (Li);granulocyte‐macrophage progenitor cells (GM‐CFC);colony‐stimulating factor (CSF);human placenta‐conditioned medium (HPCM);granulopoietic differentiation

 

数据来源: WILEY

 

摘要:

AbstractInterferon has been shown to inhibit erythropoietic and granulopoietic differentiation. Since lithium carbonate (Li) elevates granulocyte levels in a variety of neutropenic disorders, we investigated the effect of Li on human leukocyte interferon (HLIF)‐mediated inhibition of granulopoietic differentiation. Using an agar culture technique for cloning granulocyte‐macrophage progenitor cells (GM‐CFC), we demonstrated that Li blocks HLIF‐induced granulopoietic differentiation arrest in a dose‐dependent manner. Results of removal of T lymphocytes from marrow cells suggest that this Li effect is not mediated through marrow T ly

 

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