COLLINS, M. A., K. J. CURETON, D. W. HILL, and C. A. RAY. Relation of plasma volume change to intensity of weight lifting.Med. Sci. Sports Exerc, Vol. 21, No. 2, pp. 178–185, 1989. To determine the relation of plasma volume change to intensity of weight lifting, blood samples were obtained from 15 males [mean (±SD) age = 22.3 ± 3.2 yr; height = 176.3 ± 6.9 cm; weight = 73.0 · 11.7 kg] before and over a 60-min period following weight lifting at four different intensities [40, 50, 60, and 70% of one-repetition maximum (1-RM)]. Weight lifting consisted of completing three circuits of four exercises (bench press, bent-over row, arm curl, and parallel squat), with 10 repetitions of each exercise performed over a 30-s period followed by 30 s of rest. Mean (±SE) oxygen uptakes (&OV0312;O2) during weight lifting at the four intensities were 1.31 ± 0.04, 1.50 ± 0.07, 1.72 ± 0.07, and 1.86±0.08 1·min-1, or 33–47% of treadmill-determined &OV0312;O2maxrespectively. Mean (±SE) blood lactates were 6.5 ± 0.5, 8.7 ± 0.5, 9.4 ± 0.6, and 12.0 ± 0.6 mmol·l-1, respectively. Mean (±SE) heart rates (HR) were 124 ± 4, 134 ± 4, 148 ± 5, and 161 ± 4 bpm, or 63–82% of treadmill-determined HRmax, respectively. Plasma volume decreased linearly in relation to intensity of weight lifting with mean responses of −7.7 ± 0.8, −10.7 ± 0.8, −12.1 ± 0.9, and −13.9 ± 0.8% at 40, 50, 60, and 70% of 1-RM, respectively. It was concluded that plasma volume decreases linearly in relation to intensity (%1-RM) of weight lifting and that the relation is similar to that reported for dynamic, low-resistance exercise such as cycling and running.