The Simultaneous Identification of Metoprolol and Its Major Acidic and Basic Metabolites in Human Urine by Gas Chromatography-Mass Spectrometry
作者:
F Li,
SF. Cooper,
期刊:
Instrumentation Science & Technology
(Taylor Available online 1996)
卷期:
Volume 24,
issue 1
页码: 13-22
ISSN:1073-9149
年代: 1996
DOI:10.1080/10739149608000462
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A novel gas chromatography-mass spectrometric (GC-MS) method was developed to confirm and identify metoprolol and its metabolites by double derivatization with S-(-)menthyl chloroformate [(-)-MCF] and N-methyl-(trimethylsilyl)-trifluoroacetamide (MSTFA). This is the first report, which describes the simultaneous identification of metoprolol, its one major acidic and other basic metabolites in human urine based on solid-phase extraction with C18reversed-phase cartridges.
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