Functional α1‐adrenoceptors in the rat heart during β‐receptor blockade
作者:
J. A. ASK,
G. STENE‐LARSEN,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1984)
卷期:
Volume 120,
issue 1
页码: 7-13
ISSN:0001-6772
年代: 1984
DOI:10.1111/j.1748-1716.1984.tb07366.x
出版商: Blackwell Publishing Ltd
关键词: α1‐receptors during β‐blockade;rat atrium and ventricle;normal temperature (37.5°C) and heart rate (4 Hz)
数据来源: WILEY
摘要:
In absence of β‐receptor blocking agents, α‐adrenergic inotropic effects could be demonstrated in the rat myocardium for the synthetic α‐agonists phenylephrine and methoxamine, but not for the naturally occurring catecholamines, adrenaline and noradrenaline. Other synthetic α‐agonists were without effects. In the presence of the β‐receptor blocking agent, propranolol or timolol, marked α‐effects were demonstrated for adrenaline and noradrenaline in both the right and left atria and the right ventricle. The results indicate that α‐receptors may be functionally important in the
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