Segregation and Linkage Analyses of 72 Leprosy Pedigrees
作者:
R.W.C. Haile,
L. Iselius,
P.E.M. Fine,
N.E. Morton,
期刊:
Human Heredity
(Karger Available online 1985)
卷期:
Volume 35,
issue 1
页码: 43-52
ISSN:0001-5652
年代: 1985
DOI:10.1159/000153514
出版商: S. Karger AG
关键词: Leprosy;Genetic susceptibility;HLA;Linkage;Linkage disequilibrium
数据来源: Karger
摘要:
Data on 72 families with multiple cases of leprosy were analyzed for a susceptibility gene linked to the HLA loci. We conducted segregation analysis with the program POINTER and identity of HLA types by descent analysis to determine the most likely mode of inheritance. We then conducted linkage analysis with the program LINKAS, first assuming linkage equilibrium and then allowing for linkage disequilibrium and etiological heterogeneity. Segregation results suggest a recessive mode of inheritance, especially for the tuberculoid forms of leprosy. The linkage results, limited to tuberculoid forms and assuming a recessive model, suggest a hypothesis of loose linkage with no unlinked locus. When an additive model is assumed, the best fit is obtained with a hypothesis of complete linkage (θ = 0.0) with heterogeneity. We currently favor the additive model as the more plausible one.
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