Beneficial Effect of Hepatic Arterialization on Hypogonadism in Male Rats with Portacaval Shunt
作者:
J. Rozga,
G. Flati,
A. Tenenbaum,
Lena Andersson,
B. Jeppsson,
S. Bengmark,
期刊:
European Surgical Research
(Karger Available online 1990)
卷期:
Volume 22,
issue 1
页码: 34-40
ISSN:0014-312X
年代: 1990
DOI:10.1159/000129080
出版商: S. Karger AG
关键词: Portacaval shunt;Liver cirrhosis;Hypogonadism;Steroids;Testes
数据来源: Karger
摘要:
The effect of portacaval shunt (PCS) with and without hepatic arterialization (HA) upon the liver morphology, hemodynamics, and in relation to testicular weight, histology, and plasma sex steroid levels has been investigated in male rats. PCS rats showed a significant decrease in hepatic blood flow, body and liver weights, together with signs of severe hypogonadism. In contrast, in HA rats the increment in liver blood flow was associated with higher body and liver weights. In spite of total portal blood shunting, a beneficial effect on testicular morphology and an increase in plasma testosterone level were observed. In respect to plasma estradiol levels the intergroup differences could not be evaluated due to large individual variations. This was probably caused by the presence of cross-reactive plasma component(s) masking the level of endogenous estrogen. It is concluded that portosystemic shunting is not of primary importance in the etiology of PCS-related hypogonadism in the male.
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