Efficacy of Once- versus Thrice-Weekly Subcutaneous Recombinant Human Erythropoietin in Children Receiving Continuous Cycling Peritoneal Dialysis
作者:
José Ramon C. Ongkingco,
Edward J. Ruley,
Mary.E. Turner,
Mary R. Fragale,
期刊:
American Journal of Nephrology
(Karger Available online 1994)
卷期:
Volume 14,
issue 1
页码: 14-18
ISSN:0250-8095
年代: 1994
DOI:10.1159/000168680
出版商: S. Karger AG
关键词: End-stage renal disease;anemia;Recombinant human erythropoietin;weekly dosing;Single-dose pharmacokinetic studies;subcutaneous route
数据来源: Karger
摘要:
The subcutaneous administration of recombinant human erythropoietin is effective in the treatment of anemia of end-stage renal disease. Single-dose pharmacokinetic studies suggest the possibility of less frequent dosing via the subcutaneous route. In this study, dosing once-weekly was as effective as thrice-weekly subcutaneous dosing in maintaining the corrected hematocrit in a group of children receiving continuous cycling peritoneal dialysis. This regimen was preferred by and benificial to both patients and their parents.
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