Changes in Beta-Adrenergic Receptors under Long-Term Application of Ritodrine in Pregnant-Rat Myometrium
作者:
Tatsuhiko Kawarabayashi,
Takuji Tsukamoto,
Yuji Kaneko,
Masahiko Ikeda,
Hajime Sugimori,
Koichi Shirakawa,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1993)
卷期:
Volume 35,
issue 3
页码: 136-139
ISSN:0378-7346
年代: 1993
DOI:10.1159/000292683
出版商: S. Karger AG
关键词: Myometrium;Ritodrine;β-Receptor density
数据来源: Karger
摘要:
Changes in β-adrenergic receptor density under long-term application of ritodrine were investigated using longitudinal muscle strips of day-21-pregnant-rat myometrium. Membrane (––)[3H]dihydroalprenolol binding sites were increased by 3.1 × 10––8 Mritodrine, with a maximum increase at 3.1 × 10––7M, followed by a gradual decrease at higher concentrations. Under long-term application of a lower dose (1.5 × 10––7M) of ritodrine, the number of the binding sites increased up to 20 min, then decreased to the control level and fluctuated after 90 min. These results suggest that at lower doses, ritodrine might activate adenylate cyclase, resulting in conformational changes in the receptors, and that receptor density might vary in parallel with cellular cAMP production under long-term application of ritodrine.
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