Changing ideas on chloroquine inPlasmodium falciparum
作者:
Cecilia Sanchez,
Michael Lanzer,
期刊:
Current Opinion in Infectious Diseases
(OVID Available online 2000)
卷期:
Volume 13,
issue 6
页码: 653-658
ISSN:0951-7375
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
For 40 years scientists have hotly debated the questions of how chloroquine kills malarial parasites and how resistance to this once first-line antimalarial drug has evolved. While an end to these debates is not in sight, as a result of the complexity of the subject, new findings have come forward that give the discussion a new direction. In this paper we will summarize current knowledge on chloroquine's antimalarial mode of action and the genesis of the resistant phenotype in the human malarial parasitePlasmodium falciparum, with special emphasis on the most recent developments in this field.
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