Immunohistochemical Study on the Expression of c-erbB-2 Oncoprotein in Breast Cancer
作者:
Jun Horiguchi,
Yuichi Iino,
Hiroyuki Takei,
Takao Yokoe,
Tsunehiro Ishida,
Yasuo Morishita,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 1
页码: 47-51
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227309
出版商: S. Karger AG
关键词: Breast cancer;survival;c-erbB-2 oncoprotein;Immunohistochemistry
数据来源: Karger
摘要:
Expression of the c-erbB-2 oncogene protein was investigated by immunohistochemistry in 110 paraffin-embedded blocks of primary breast cancer. 25 (22.7%) of 110 tumors were stained positively with c-erbB-2 protein antibody. There was no correlation between c-erbB-2 immunostaining and age at diagnosis, menopausal status, hormone receptor status, tumor size, or clinical stage. The tumors with an extensive intraductal component showed a higher incidence of the c-erbB-2 expression than those without. A significantly shorter overall survival was obtained in patients with the expression of c-erbB-2 protein than in patients without. Staining of c-erbB-2 protein is an effective prognostic indicator in patients with breast cancer.
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