Pharmacologic Dilatation of the Ductus Arteriosus With Prostaglandin E1in Infants With Congenital Heart Disease
作者:
THOMAS,
GRAHAM GERALD,
ATWOOD ROBERT,
期刊:
Southern Medical Journal
(OVID Available online 1978)
卷期:
Volume 71,
issue 10
页码: 1238-1241
ISSN:0038-4348
年代: 1978
出版商: OVID
数据来源: OVID
摘要:
Prostaglandin E1(PGE1) has been used for successful palliation in nine infants with congenital heart disease. Seven patients had pulmonary atresia with ductal-dependent pulmonary blood flow. In this group, systemic O2saturation increased from a mean value of 45% to 79% after infusion of PGE1, and surgical palliation was successfully done with the infants in stable condition, without hypoxemia or acidemia. An additional patient with coarctation of the aorta had marked ductal dilatation after PGE1infusion, as indicated by umbilical artery pulse pressure. The coarctation was repaired, with the infant in stable condition. The final patient had neonatal tricuspid insufficiency with right-to-left atrial shunting. Systemic O2saturation was improved after PGE1infusion, though the ductus was closed. The improved oxygenation was believed to be due to a reduction in pulmonary vascular resistance by PGE1. Prostaglandin E1provides a powerful new tool for palliation of critical congenital heart disease in infants whose ductal constriction can markedly influence their clinical status.
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