Topical use of calcipotriol does not potentiate squaric acid dibutylester effectiveness in the treatment of alopecia areata
作者:
OrecchiaG,
RocchettiG Albani,
期刊:
Journal of Dermatological Treatment
(Taylor Available online 1995)
卷期:
Volume 6,
issue 1
页码: 21-23
ISSN:0954-6634
年代: 1995
DOI:10.3109/09546639509080585
出版商: Taylor&Francis
关键词: Calcipotriol;SADBE;Alopecia areata
数据来源: Taylor
摘要:
As calcipotriol has been reported to increase mitotic activity, to have a role in regulating immune response and to increase the contact hypersensitivity response when applied topically at the elicitation site we sought to determine whether topical calcipotriol is able to potentiate the response to squaric acid dibutylester (SADBE) in severe alopecia areata. A group of 28 subjects with severe alopecia areata were sensitized with a 2% SADBE solution applied to the vertex. After 2 weeks and then weekly, a 0.001% SADBE solution was applied to the whole scalp. Every day, except the day of SADBE application, an ointment containing 50μg/g calcipotriol was applied to the left side of the scalp. Treatment with calcipotriol and SADBE did not significantly potentiate hair growth (P= 0.133). This study suggests that calcipotriol has an inhibiting action on cell multiplication.
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