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Topical use of calcipotriol does not potentiate squaric acid dibutylester effectiveness in the treatment of alopecia areata

 

作者: OrecchiaG,   RocchettiG Albani,  

 

期刊: Journal of Dermatological Treatment  (Taylor Available online 1995)
卷期: Volume 6, issue 1  

页码: 21-23

 

ISSN:0954-6634

 

年代: 1995

 

DOI:10.3109/09546639509080585

 

出版商: Taylor&Francis

 

关键词: Calcipotriol;SADBE;Alopecia areata

 

数据来源: Taylor

 

摘要:

As calcipotriol has been reported to increase mitotic activity, to have a role in regulating immune response and to increase the contact hypersensitivity response when applied topically at the elicitation site we sought to determine whether topical calcipotriol is able to potentiate the response to squaric acid dibutylester (SADBE) in severe alopecia areata. A group of 28 subjects with severe alopecia areata were sensitized with a 2% SADBE solution applied to the vertex. After 2 weeks and then weekly, a 0.001% SADBE solution was applied to the whole scalp. Every day, except the day of SADBE application, an ointment containing 50μg/g calcipotriol was applied to the left side of the scalp. Treatment with calcipotriol and SADBE did not significantly potentiate hair growth (P= 0.133). This study suggests that calcipotriol has an inhibiting action on cell multiplication.

 

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