Leiomyosarcoma of the Uterus: Ultrasonography and Serum Lactate Dehydrogenase Level
作者:
K. Seki,
T. Hoshihara,
I. Nagata,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1992)
卷期:
Volume 33,
issue 2
页码: 114-118
ISSN:0378-7346
年代: 1992
DOI:10.1159/000294861
出版商: S. Karger AG
关键词: Leiomyosarcoma;Uterus;Ultrasonography;Lactate dehydrogenase
数据来源: Karger
摘要:
Between January 1 1979, and September 30, 1990, a total of 1,886 patients in the National Defense Medical College Hospital, a self-referred population, had a hysterectomy because of signs and symptoms presumably resulting from uterine myomas. After hysterectomy with presumed benign disease, a histologic diagnosis of leiomyosarcoma was made in 7 patients (0.37%). Preoperative diagnosis of leiomyosarcoma was not made in any of the 7 patients. However, serum lactate dehydrogenase levels were abnormally elevated in 3 of them, and degenerative changes were found within the tumor by ultrasonography in 5 of them. Furthermore, increased lactate dehydrogenase levels and degenerative changes within the tumor were found in 3 of the patients whose tumors had 10 or more mitoses per 10 high-power fields. The prognosis for the leiomyosarcomas with increased mitotic rates is very poor. Therefore, a degenerative change within the uterine mass and an increased lactate dehydrogenase level, when present, should suggest the diagnosis of leiomyosarcoma.
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