Complement Receptors (CR) and Cytotoxic Responses: Monoclonal Antibodies Directed Against CR1 AMD CR3 Inhibit the Generation of Human Allospecific and Virus Specific Cytotoxic Cells in Vitro
作者:
InghiramiGiorgio,
LambrisJohn D.,
TsokosGeorge C.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 1
页码: 75-88
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609031086
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractA variety of cellular immune responses involve complement factors which bind to specific receptors, and modulate or effect a specific reaction. Monoclonal antibodies (MAb) have been generated against complement receptors (CR) 1 and 3, which were utilized to investigate human allogeneic and Epstein-Barr virus specific cytotoxic cells in vitro. MAb OKM1, which binds to the C3bi CR (CR3), and MAb M710, which binds to the C3b/4b CR (CR1), inhibited the generation of both allogeneic and virus specific cytotoxic responses in vitro in a dose-dependent way; doses of 1μg/ml (or greater) completely abrogated the cytotoxic responses. Inibition of these responses was observed when the MAb was added to the cultures at any time point except the last two days. In addition, treatment of the responder (but not the stimulator cells) with either MAb resulted in complete inhibition of cytotoxic responses. These experiment indicate that complement receptors participate in the generation of human cytotoxic responses in vitro.
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