ENHANCING EFFECT OF SURGICAL BURSECTOMY ON ANTIBODY RESPONSE
作者:
YOSHIKAZU HIROTA,
OLLI VAINIO,
PAAVO TOIVANEN,
期刊:
Acta Pathologica Microbiologica Scandinavica Section C Immunology
(WILEY Available online 1981)
卷期:
Volume 89C,
issue 1‐6
页码: 35-42
ISSN:0304-1328
年代: 1981
DOI:10.1111/j.1699-0463.1981.tb02662.x
出版商: Blackwell Publishing Ltd
关键词: Bursa of Fabricius;suppressor cells
数据来源: WILEY
摘要:
Effect of surgical bursectomy on antibody response was studied in chicks injected intrabursally with sheep red blood cells (SRBC) andBrucella abortuson day 2 of life and challenged intravenously with the same antigens on day 9. Bursectomy performed 2 days after the priming resulted in a significantly decreased anti‐SRBC plaque‐forming cell (PFC) response, whereas bursectomy performed 4 or 5 days after the priming clearly enhanced the PFC response. The enhancing effect of bursectomy on the PFC response was also observed if the priming was made intravenously. In antibody titers against SRBC the enhancing effect was observed only if a secondary and tertiary challenge was performed at the age of 28 and 36 days, respectively. Titers ofBrucellaantibodies were either reduced by the bursectomy (performed 2 or 4 days after the intrabursal priming) or left unaffected (bursectomy performed 5 days after the priming). These findings are discussed in relation to bursa‐derived suppressor
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