Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function
作者:
Mitsuo Ohkawa,
Kyoichi Kuroda,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 4
页码: 242-247
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237912
出版商: S. Karger AG
关键词: Pharmacokinetics of ceftezole;Impaired renal function;Drip infusion
数据来源: Karger
摘要:
The pharmacokinetics of ceftezole, a new cephalosporin antibiotic, was studied in 15 patients with normal and impaired renal function after administering the drug in a 2-hour intravenous drip infusion of 2 g, 81% of the infused dose was excreted in the first 6 h urine of the patients with normal renal function. The pharmacokinetic parameters of ceftezole were obtained by analyzing the serum level data of the drug using a one-compartment open model. The mean serum half-life of ceftezole was 0.64 h in patients with normal renal function and was prolonged to 10.7 h in patients with severely impaired renal function (creatinine clearance: 0-2.6 ml/min.). There was a significant linear correlation between the elimination rate of the drug and creatinine clearance.
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