High-Dose Folinic Acid and 5-Fluorouracil in Advanced Colorectal Cancer
作者:
Di CostanzoFrancesco,
BartolucciRoberta,
PadalinoDomenico,
BrugiaMauro,
BuzziFranco,
期刊:
Cancer Investigation
(Taylor Available online 1988)
卷期:
Volume 6,
issue 2
页码: 133-138
ISSN:0735-7907
年代: 1988
DOI:10.3109/07357908809077040
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractTwenty-three patients with advanced colorectal cancer were treated with folinic acid (200 mg/m2/day 1-5IV bolus injection) and 5-fluorouracil (400 mg/m2/day 1-5 IV in 15 minutes) every 28 days. Only three patients were pretreated. Objective response was observed in 6 (30%) of 20 evaluable patients (three complete and three partial responses). The median duration of response was 9 months (range 5-15) and time to disease progression ranged from 2 to 12 months (median 6 months). Median survival was 21 months (range 12-23+) for responders. Another 6 (30%) patients had stabilization of disease. Toxicity was generally gastrointestinal (mucositis, diarrhea, nausea); moderate leukopenia was noted. The response rate found in this study indicates that folinic acid administered in high doses enhances the effectiveness of 5-FU administered concomitantly in colorectal cancer.
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