Ultrastructural Changes in Neonatal Liver Tissue: Effects of Maternal Drinking
作者:
K.S. Amankwah,
R.C. Kaufmann,
Aruna D. Weberg,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1984)
卷期:
Volume 17,
issue 4
页码: 213-218
ISSN:0378-7346
年代: 1984
DOI:10.1159/000299151
出版商: S. Karger AG
关键词: Alcohol;Maternal drinking;Neonate;Liver tissue;Hepatic necrosis;Ultrastructural changes
数据来源: Karger
摘要:
There is already sufficient evidence in the literature that alcohol abuse during pregnancy has a toxic effect upon the developing fetus; however, previous studies have not revealed any morphological changes in fetal or newborn liver specimens from animals exposed to alcohol in utero. As it is known that alcohol freely crosses the placental barrier, this investigation was an attempt to demonstrate that structural abnormalities can indeed be identified in neonatal mouse liver specimens from pups exposed to alcohol in utero. Chosen as a model for this study was the C57BL/KsJ mouse strain as this particular animal demonstrates an alcohol preference paralleling that of the human alcoholic. Findings appear to indicate the presence of abnormal changes on the morphological level in these study animals.
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