A quantitative analysis of the development of the central nervous system in juvenileAplysia californica
作者:
Dave Cash,
Thomas J. Carew,
期刊:
Journal of Neurobiology
(WILEY Available online 1989)
卷期:
Volume 20,
issue 1
页码: 25-47
ISSN:0022-3034
年代: 1989
DOI:10.1002/neu.480200104
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe marine molluscAplysia californicahas proved to be a useful preparation for analyzing the development of learning and memory on both behavioral and cellular levels. An important issue in this analysis concerns the anatomical substrate upon which learning is superimposed during development. As a first step in examining this question, in the present study we have determined the number of neurons in all the major central ganglia at each stage during juvenile development, a time when several forms of learning first emerge inAplysia. We found that a large and highly nonlinear proliferation of neurons occurs during juvenile development, with the greatest increase in cell number occurring during a specific juvenile stage: Stage 12. The neuronal proliferation is system‐wide, occurring in each of the central ganglia simultaneously, suggesting the action of a general developmental signal or trigger (perhaps a hormone). Accompanying the increase in neuron number in Stage 12 there is a large increase in neuropilar volume (150‐fold), which significantly increases the opportunity for synaptic interactions late in juvenile developm
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